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GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

BACKGROUND: Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail. METHODS: The expression of GPX4 in EC tissues was determined by TCGA databases, qRT-PCR, Western blot,...

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Detalles Bibliográficos
Autores principales:	Wei, Sitian, Yu, Zhicheng, Shi, Rui, An, Lanfen, Zhang, Qi, Zhang, Qian, Zhang, Tangansu, Zhang, Jun, Wang, Hongbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373394/ https://www.ncbi.nlm.nih.gov/pubmed/35962333 http://dx.doi.org/10.1186/s12885-022-09986-3

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