GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation

Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated with the pathophysiology of Alzheimer’s disease (AD). However, GRKs have not been directly implicated in regulation of the amyloid-β (Aβ) pathogenic cascade in AD. Here, we determine that GRKs phosphoryla...

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Detalles Bibliográficos
Autores principales: Todd, Nicholas K., Huang, Yunhong, Lee, Ji Young, Doruker, Pemra, Krieger, James M., Salisbury, Ryan, MacDonald, Matthew, Bahar, Ivet, Thathiah, Amantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373432/
https://www.ncbi.nlm.nih.gov/pubmed/35858570
http://dx.doi.org/10.1016/j.celrep.2022.111110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373432/
https://www.ncbi.nlm.nih.gov/pubmed/35858570
http://dx.doi.org/10.1016/j.celrep.2022.111110

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