Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in mouse macrophage RAW264.7 cells. The present studies evaluate neurosteroid actions upon TLR activation in human macrophages...

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Detalles Bibliográficos
Autores principales: Balan, Irina, Aurelian, Laure, Williams, Kimberly S., Campbell, Brian, Meeker, Rick B., Morrow, A. Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373802/
https://www.ncbi.nlm.nih.gov/pubmed/35967446
http://dx.doi.org/10.3389/fimmu.2022.940095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373802/
https://www.ncbi.nlm.nih.gov/pubmed/35967446
http://dx.doi.org/10.3389/fimmu.2022.940095

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