Cargando…

RNA N(6)-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer

RNA N(6)-methyladenosine (m(6)A) modification and its regulators fine tune gene expression and contribute to tumorigenesis. This study aims to uncover the essential role and the underlying molecular mechanism(s) of the m(6)A reader YTHDC1 in promoting triple negative breast cancer (TNBC) metastasis....

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Brandon, Zhou, Keren, Liu, Wei, Prince, Emily, Qing, Ying, Li, Yangchan, Han, Li, Qin, Xi, Su, Rui, Pokharel, Sheela Pangeni, Yang, Lu, Zhao, Zhicong, Shen, Chao, Li, Wei, Chen, Zhenhua, Zhang, Zheng, Deng, Xiaolan, Small, Andrew, Wang, Kitty, Leung, Keith, Chen, Chun-Wei, Shen, Binghui, Chen, Jianjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373808/ https://www.ncbi.nlm.nih.gov/pubmed/35966596 http://dx.doi.org/10.7150/thno.71872

Ejemplares similares

The N6-methyladenosine reader protein YTHDC2 promotes gastric cancer progression via enhancing YAP mRNA translation
por: Yuan, Wei, et al.
Publicado: (2021)

N(6)-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication
por: Zhu, Yinxing, et al.
Publicado: (2023)

RNA m(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression
por: Zhang, Zheng, et al.
Publicado: (2023)

The Effect of N6-Methyladenosine Regulators and m6A Reader YTHDC1-Mediated N6-Methyladenosine Modification Is Involved in Oxidative Stress in Human Aortic Dissection
por: Yin, Fanxing, et al.
Publicado: (2023)

m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
por: Liang, Diefei, et al.
Publicado: (2021)

YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs
por: Roundtree, Ian A, et al.
Publicado: (2017)

Depletion of m(6)A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin
por: Gao, Siyun, et al.
Publicado: (2021)

Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases
por: Yan, Huaqing, et al.
Publicado: (2022)

The m6A RNA Modification Quantity and the Prognostic Effect of Reader YTHDC2 in Colorectal Cancer
por: Liu, Tianyu, et al.
Publicado: (2022)

Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
por: Chen, Chuan, et al.
Publicado: (2021)

The roles and therapeutic implications of messenger RNA internal N (7)‐methylguanosine and N (6)‐methyladenosine modifications in chemoresistance
por: Zhao, Zhicong, et al.
Publicado: (2023)

Correction to: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
por: Chen, Chuan, et al.
Publicado: (2021)

YTHDC2-Mediated circYTHDC2 N6-Methyladenosine Modification Promotes Vascular Smooth Muscle Cells Dysfunction Through Inhibiting Ten-Eleven Translocation 2
por: Yuan, Jun, et al.
Publicado: (2021)

Main N6-Methyladenosine Readers: YTH Family Proteins in Cancers
por: Dai, Xin-Yuan, et al.
Publicado: (2021)

Pathogenic variants in the human m(6)A reader YTHDC2 are associated with primary ovarian insufficiency
por: McGlacken-Byrne, Sinéad M., et al.
Publicado: (2022)

The m6A reader YTHDC1 regulates muscle stem cell proliferation via PI4K–Akt–mTOR signalling
por: Liu, Jin, et al.
Publicado: (2023)

m(6)A Reader: Epitranscriptome Target Prediction and Functional Characterization of N(6)-Methyladenosine (m(6)A) Readers
por: Zhen, Di, et al.
Publicado: (2020)

The m(6)A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay
por: Macveigh-Fierro, Daniel, et al.
Publicado: (2022)

Downregulation of m(6)A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway
por: Wang, Jin, et al.
Publicado: (2021)

Nuclear Aurora kinase A switches m(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4
por: Li, SiSi, et al.
Publicado: (2022)

Nuclear m(6)A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
por: Kasowitz, Seth D., et al.
Publicado: (2018)

N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms
por: Chen, Lin, et al.
Publicado: (2023)

Identification and verification of IGFBP3 and YTHDC1 as biomarkers associated with immune infiltration and mitophagy in hypertrophic cardiomyopathy
por: Li, Yao, et al.
Publicado: (2022)

The m6A reader protein YTHDC2 is a potential biomarker and associated with immune infiltration in head and neck squamous cell carcinoma
por: Li, Yang, et al.
Publicado: (2020)

The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′–3′ exoribonuclease XRN1
por: Kretschmer, Jens, et al.
Publicado: (2018)

Multiple Phosphorylations of SR Protein SRSF3 and Its Binding to m(6)A Reader YTHDC1 in Human Cells
por: Tatsuno, Takanori, et al.
Publicado: (2022)

The m(6)A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs
por: Dattilo, Dario, et al.
Publicado: (2023)

The m(6)A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
por: Ma, Lifang, et al.
Publicado: (2020)

Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study
por: Li, Yangchan, et al.
Publicado: (2020)

Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export
por: Qiao, Yulong, et al.
Publicado: (2023)

RNA N(6)-methyladenosine modification in cancers: current status and perspectives
por: Deng, Xiaolan, et al.
Publicado: (2018)

Association of N6-methyladenosine readers' genes variation and expression level with pulmonary tuberculosis
por: Li, Hong-Miao, et al.
Publicado: (2022)

YTHDC1 gene polymorphisms and neuroblastoma susceptibility in Chinese children
por: Li, Yong, et al.
Publicado: (2021)

A potassium-chloride co-transporter promotes tumor progression and castration resistance of prostate cancer through m(6)A reader YTHDC1
por: Yuan, Shuai, et al.
Publicado: (2023)

m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis
por: He, Jun-Ju, et al.
Publicado: (2020)

Downregulation of m(6)A reader YTHDC2 promotes tumor progression and predicts poor prognosis in non‐small cell lung cancer
por: Sun, Shulei, et al.
Publicado: (2020)

Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis
por: Wang, Xiaogang, et al.
Publicado: (2023)

N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer
por: Lu, Senxu, et al.
Publicado: (2021)

YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
por: Yang, Heng, et al.
Publicado: (2022)

The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression
por: Jin, Zhe, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_etm6g4tftbl007pg3mb2rjk170