MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation

Rationale: GLK (MAP4K3) activates PKCθ-IKKβ axis in T-cell activation and induces IL-17A-mediated autoimmune diseases. Attenuation of Treg differentiation and function by GLK could also contribute to autoimmune diseases. Methods: We analyzed the roles of GLK and IKKβ in Treg differentiation and func...

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Detalles Bibliográficos
Autores principales: Chi, Jyun-Ni, Yang, Jhih-Yu, Hsueh, Chia-Hsin, Tsai, Ching-Yi, Chuang, Huai-Chia, Tan, Tse-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373822/
https://www.ncbi.nlm.nih.gov/pubmed/35966593
http://dx.doi.org/10.7150/thno.72148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373822/
https://www.ncbi.nlm.nih.gov/pubmed/35966593
http://dx.doi.org/10.7150/thno.72148

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