Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges

Indoleamine 2.3-dioxygenases (IDO1/2) and tryptophan 2.3-dioxygenase (TDO) are the initial and rate-limiting enzymes in tryptophan metabolism, which play an essential role in mediating immunosuppression in tumor microenvironment. Accumulating evidence has indicated that both IDO1 and TDO are highly...

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Detalles Bibliográficos
Autores principales: Peng, Xuerun, Zhao, Zhipeng, Liu, Liwen, Bai, Lan, Tong, Rongsheng, Yang, Hao, Zhong, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374094/
https://www.ncbi.nlm.nih.gov/pubmed/35965963
http://dx.doi.org/10.2147/DDDT.S373780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374094/
https://www.ncbi.nlm.nih.gov/pubmed/35965963
http://dx.doi.org/10.2147/DDDT.S373780

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