Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors

Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1. Here we show that fusions between EWS and GGAA-repeat-targeted engineered zinc finger arrays (ZFA...

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Detalles Bibliográficos
Autores principales: Tak, Y. Esther, Boulay, Gaylor, Lee, Lukuo, Iyer, Sowmya, Perry, Nicholas T., Schultz, Hayley T., Garcia, Sara P., Broye, Liliane, Horng, Joy E., Rengarajan, Shruthi, Naigles, Beverly, Volorio, Angela, Sander, Jeffry D., Gong, Jingyi, Riggi, Nicolò, Joung, J. Keith, Rivera, Miguel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374162/
https://www.ncbi.nlm.nih.gov/pubmed/35967079
http://dx.doi.org/10.1016/j.xgen.2022.100119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374162/
https://www.ncbi.nlm.nih.gov/pubmed/35967079
http://dx.doi.org/10.1016/j.xgen.2022.100119

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