Cargando…

Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes

RAS genes are the most frequently mutated oncogenes in cancer, yet the effects of oncogenic RAS signaling on the noncoding transcriptome remain unclear. We analyzed the transcriptomes of human airway and bronchial epithelial cells transformed with mutant KRAS to define the landscape of KRAS-regulate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reggiardo, Roman E., Maroli, Sreelakshmi Velandi, Halasz, Haley, Ozen, Mehmet, Hrabeta-Robinson, Eva, Behera, Amit, Peddu, Vikas, Carrillo, David, LaMontagne, Erin, Whitehead, Lila, Kim, Eejung, Malik, Shivani, Fernandes, Jason, Marinov, Georgi, Collisson, Eric, Brooks, Angela, Demirci, Utkan, Kim, Daniel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374308/ https://www.ncbi.nlm.nih.gov/pubmed/35858545 http://dx.doi.org/10.1016/j.celrep.2022.111104

Ejemplares similares

Transposable element RNA dysregulation in mutant KRAS(G12C) 3D lung cancer spheroids
por: Carrillo, David, et al.
Publicado: (2023)

Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-Containing Zinc Finger Proteins
por: Wang, Wei, et al.
Publicado: (2014)

PEG3 Interacts with KAP1 through KRAB-A
por: He, Hongzhi, et al.
Publicado: (2016)

ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes
por: Osipovich, Anna B., et al.
Publicado: (2023)

The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain
por: Lorenz, Peter, et al.
Publicado: (2022)

KRAB-containing zinc-finger repressor proteins
por: Urrutia, Raul
Publicado: (2003)

KRAB-ZFPs and cancer stem cells identity
por: Olechnowicz, Anna, et al.
Publicado: (2022)

Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs
por: O'Geen, Henriette, et al.
Publicado: (2007)

Kruppel-associated box (KRAB) proteins in the adaptive immune system
por: Santoni de Sio, Francesca R
Publicado: (2014)

Structure and functional mapping of the KRAB‐KAP1 repressor complex
por: Stoll, Guido A, et al.
Publicado: (2022)

Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9
por: Zhang, Yang, et al.
Publicado: (2022)

The PRDM9 KRAB domain is required for meiosis and involved in protein interactions
por: Imai, Yukiko, et al.
Publicado: (2017)

Evolving imprinting control regions: KRAB zinc fingers hold the key
por: Juan, Aimee M., et al.
Publicado: (2019)

KRAB-ZFP Transcriptional Regulators Acting as Oncogenes and Tumor Suppressors: An Overview
por: Sobocińska, Joanna, et al.
Publicado: (2021)

KRAB family is involved in network shifts in response to osmotic stress in camels
por: Cao, Dandan, et al.
Publicado: (2022)

Genetic features and genomic targets of human KRAB-zinc finger proteins
por: de Tribolet-Hardy, Jonas, et al.
Publicado: (2023)

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
por: Helleboid, Pierre‐Yves, et al.
Publicado: (2019)

Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer
por: Ye, Qing, et al.
Publicado: (2021)

KRAB zinc finger protein diversification drives mammalian interindividual methylation variability
por: Bertozzi, Tessa M., et al.
Publicado: (2020)

Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions
por: Yang, Bo, et al.
Publicado: (2022)

Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
por: Wang, Man-Tzu, et al.
Publicado: (2019)

KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions
por: Lupo, Angelo, et al.
Publicado: (2013)

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
por: Wolf, Gernot, et al.
Publicado: (2020)

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression
por: Ito, Jumpei, et al.
Publicado: (2020)

Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells
por: Chauvin, Anaïs, et al.
Publicado: (2022)

Structural Evolution of Gene Promoters Driven by Primate-Specific KRAB Zinc Finger Proteins
por: Farmiloe, Grace, et al.
Publicado: (2023)

A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties
por: Zhang, Yuqian, et al.
Publicado: (2022)

Identification of target genes for spermatogenic cell-specific KRAB transcription factor ZFP819 in a male germ cell line
por: Jin, Sora, et al.
Publicado: (2017)

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1
por: Chan, D, et al.
Publicado: (2003)

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses
por: Wolf, Gernot, et al.
Publicado: (2015)

KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells
por: Kumar, Janani, et al.
Publicado: (2020)

Downregulation of CacyBP by CRISPR/dCas9-KRAB Prevents Bladder Cancer Progression
por: Zheng, Hanxiong, et al.
Publicado: (2021)

KRAB-zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution
por: Otsuka, Kai, et al.
Publicado: (2023)

Quantifying the arms race between LINE-1 and KRAB-zinc finger genes through TECookbook
por: Zuo, Zheng
Publicado: (2023)

Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications
por: Asghar, Waseem, et al.
Publicado: (2016)

The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28
por: Murphy, Kristin E., et al.
Publicado: (2016)

The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data
por: Machnik, Marta, et al.
Publicado: (2019)

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
por: Turelli, Priscilla, et al.
Publicado: (2020)

The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons
por: Seah, Michelle K. Y., et al.
Publicado: (2019)

Mapping the interaction between Trim28 and the KRAB domain at the center of Trim28 silencing of endogenous retroviruses
por: Taka, Jamie R. H., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4d8pv2n6vg7s17f52ajeneidec