PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma

PFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is overexpressed in several human cancers that are associated with poor prognosis. High PFKFB3 expression in cancer stem cells promotes glycolysis and survival in the tumor microenvironment. Inhibition of PFKFB3 by the g...

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Detalles Bibliográficos
Autores principales: Thirusangu, Prabhu, Ray, Upasana, Sarkar Bhattacharya, Sayantani, Oien, Derek B., Jin, Ling, Staub, Julie, Kannan, Nagarajan, Molina, Julian R., Shridhar, Viji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374593/
https://www.ncbi.nlm.nih.gov/pubmed/35804016
http://dx.doi.org/10.1038/s41388-022-02391-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374593/
https://www.ncbi.nlm.nih.gov/pubmed/35804016
http://dx.doi.org/10.1038/s41388-022-02391-x

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