Rational peptide design for regulating liquid–liquid phase separation on the basis of residue–residue contact energy

Since liquid–liquid phase separation (LLPS) of proteins is governed by their intrinsically disordered regions (IDRs), it can be controlled by LLPS-regulators that bind to the IDRs. The artificial design of LLPS-regulators based on this mechanism can be leveraged in biological and therapeutic applica...

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Detalles Bibliográficos
Autores principales: Kamagata, Kiyoto, Ariefai, Maulana, Takahashi, Hiroto, Hando, Atsumi, Subekti, Dwiky Rendra Graha, Ikeda, Keisuke, Hirano, Atsushi, Kameda, Tomoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374670/
https://www.ncbi.nlm.nih.gov/pubmed/35962177
http://dx.doi.org/10.1038/s41598-022-17829-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374670/
https://www.ncbi.nlm.nih.gov/pubmed/35962177
http://dx.doi.org/10.1038/s41598-022-17829-1

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