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Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis

Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial persistence. Staphylococcus aureus, the predominant pathogen in human osteomyelitis, is known to persist by phenotypic adaptation as small-colony variants (SCVs) and by formation of intracellular res...

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Detalles Bibliográficos
Autores principales: Zelmer, Anja R., Nelson, Renjy, Richter, Katharina, Atkins, Gerald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374758/
https://www.ncbi.nlm.nih.gov/pubmed/35961964
http://dx.doi.org/10.1038/s41413-022-00227-8