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Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer’s disease
Accumulation of waste in cortical tissue and glymphatic waste clearance via extracellular voids partly drives the sleep-wake cycle and modeling has reproduced much of its dynamics. Here, new modeling incorporates higher void volume and clearance in sleep, multiple waste compounds, and clearance obst...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374764/ https://www.ncbi.nlm.nih.gov/pubmed/35961995 http://dx.doi.org/10.1038/s41598-022-15109-6 |