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Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARγ and reducing NOX4 expression

BACKGROUND: Sepsis is a global fatal disease and leads to severe lung injury due to dysfunction of inflammation response. TRIM27 is closely related to the diseased with dysfunction of inflammation response. The aim of this study was to clarify the role and mechanism of TRIM27 in sepsis-induced lung...

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Detalles Bibliográficos
Autores principales: Ning, Meng, Liu, Yingwu, Wang, Donglian, Wei, Jin, Hu, Guoyong, Xing, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375190/
https://www.ncbi.nlm.nih.gov/pubmed/35962797
http://dx.doi.org/10.1007/s00011-022-01625-8