Cargando…

The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases

Inosine 5′‐monophosphate dehydrogenase (IMPDH) is an evolutionarily conserved enzyme that mediates the first committed step in de novo guanine nucleotide biosynthetic pathway. It is an essential enzyme in purine nucleotide biosynthesis that modulates the metabolic flux at the branch point between ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buey, Rubén M., Fernández‐Justel, David, Jiménez, Alberto, Revuelta, José L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375230/ https://www.ncbi.nlm.nih.gov/pubmed/36040265 http://dx.doi.org/10.1002/pro.4399

Ejemplares similares

Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases
por: Buey, Rubén M., et al.
Publicado: (2015)

Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase
por: Fernández‐Justel, David, et al.
Publicado: (2022)

A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases
por: Buey, Rubén M., et al.
Publicado: (2017)

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule
por: Ferrandez, Yann, et al.
Publicado: (2017)

Metabolic engineering of Ashbya gossypii for limonene production from xylose
por: Muñoz-Fernández, Gloria, et al.
Publicado: (2022)

Utilization of xylose by engineered strains of Ashbya gossypii for the production of microbial oils
por: Díaz-Fernández, David, et al.
Publicado: (2017)

One‐vector CRISPR/Cas9 genome engineering of the industrial fungus Ashbya gossypii
por: Jiménez, Alberto, et al.
Publicado: (2019)

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments
por: Calise, S. John, et al.
Publicado: (2018)

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses
por: Martínez, José L., et al.
Publicado: (2020)

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story
por: Naffouje, Rand, et al.
Publicado: (2019)

Allosteric regulation of glutamate dehydrogenase deamination activity
por: Bera, Soumen, et al.
Publicado: (2020)

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress
por: Zhang, Qi, et al.
Publicado: (2014)

Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1
por: Joo, Emily, et al.
Publicado: (2020)

EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor
por: Gonzalez, Gilberto, et al.
Publicado: (2021)

Engineering Ashbya gossypii strains for de novo lipid production using industrial by‐products
por: Lozano‐Martínez, Patricia, et al.
Publicado: (2016)

Insights into the biological functions of Dock family guanine nucleotide exchange factors
por: Laurin, Mélanie, et al.
Publicado: (2014)

Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity
por: Kim, Youngchang, et al.
Publicado: (2015)

Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors
por: Marei, Hadir, et al.
Publicado: (2016)

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration
por: Zaritsky, Assaf, et al.
Publicado: (2017)

Structural biology of DOCK‐family guanine nucleotide exchange factors
por: Boland, Andreas, et al.
Publicado: (2022)

The many faces of the guanine-nucleotide exchange factor trio
por: van Rijssel, Jos, et al.
Publicado: (2012)

RNA structural probing of guanine and uracil nucleotides in yeast
por: Xiao, Kevin, et al.
Publicado: (2023)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
por: Kofuji, Satoshi, et al.
Publicado: (2019)

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
por: Sun, Pengkai, et al.
Publicado: (2020)

Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii
por: Ledesma-Amaro, Rodrigo, et al.
Publicado: (2015)

Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents
por: Hishiki, Takayuki, et al.
Publicado: (2023)

The Sec7 Guanine Nucleotide Exchange Factor GBF1 Regulates Membrane Recruitment of BIG1 and BIG2 Guanine Nucleotide Exchange Factors to the Trans-Golgi Network (TGN)
por: Lowery, Jason, et al.
Publicado: (2013)

A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer
por: Hsu, Tu Chun, et al.
Publicado: (2023)

A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides
Publicado: (1984)

Epigenetic Regulation of Adipocyte Differentiation by a Rho Guanine Nucleotide Exchange Factor, WGEF
por: Horii, Takuro, et al.
Publicado: (2009)

βPix Guanine Nucleotide Exchange Factor Regulates Regeneration of Injured Peripheral Axons
por: Jeon, Yewon, et al.
Publicado: (2023)

In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors
por: Nass, Karol, et al.
Publicado: (2020)

Guanine nucleotide-induced polymerization of actin in electropermeabilized human neutrophils
Publicado: (1989)

Trapp Stimulates Guanine Nucleotide Exchange on Ypt1p
por: Wang, Wei, et al.
Publicado: (2000)

Scambio, a novel guanine nucleotide exchange factor for Rho
por: Curtis, Christina, et al.
Publicado: (2004)

The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin
por: Ahmad, K. Farid, et al.
Publicado: (2010)

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes
por: Randazzo, Paul A, et al.
Publicado: (2014)

Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
por: Toti, Kiran S., et al.
Publicado: (2022)

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

Microbial biotechnology for the synthesis of (pro)vitamins, biopigments and antioxidants: challenges and opportunities
por: Revuelta, Jose L., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mvjo9isj4d7aaotrpq5jjfv1f2