Cargando…
Synthetically recoded virus sCPD9 – A tool to accelerate SARS-CoV-2 research under biosafety level 2 conditions
Research with infectious SARS-CoV-2 is complicated because it must be conducted under biosafety level 3 (BSL-3) conditions. Recently, we constructed a live attenuated SARS-CoV-2 virus by rational design through partial recoding of the SARS-CoV-2 genome and showed that the attenuated virus, designate...
Autores principales: | Kunec, Dusan, Osterrieder, Nikolaus, Trimpert, Jakob |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375251/ https://www.ncbi.nlm.nih.gov/pubmed/35992535 http://dx.doi.org/10.1016/j.csbj.2022.08.027 |
Ejemplares similares
-
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
por: Nouailles, Geraldine, et al.
Publicado: (2023) -
Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased
por: Osterrieder, Nikolaus, et al.
Publicado: (2018) -
Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization
por: Eschke, Kathrin, et al.
Publicado: (2018) -
ACE2‐Variants Indicate Potential SARS‐CoV‐2‐Susceptibility in Animals: A Molecular Dynamics Study
por: Pach, Szymon, et al.
Publicado: (2021) -
Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding
por: Trimpert, Jakob, et al.
Publicado: (2021)