Abatacept downregulates Fcγ receptor I on circulating monocytes: a potential therapeutic mechanism in patients with rheumatoid arthritis

BACKGROUND: Abatacept is a recombinant fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte antigen 4 and the Fc portion of immunoglobulin (Ig) G. The mechanism of action of abatacept in rheumatoid arthritis (RA) is believed to be competitive inhibition of T cell costimulati...

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Detalles Bibliográficos
Autores principales: Fukue, Ryosuke, Okazaki, Yuka, Gono, Takahisa, Kuwana, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375333/
https://www.ncbi.nlm.nih.gov/pubmed/35964055
http://dx.doi.org/10.1186/s13075-022-02886-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375333/
https://www.ncbi.nlm.nih.gov/pubmed/35964055
http://dx.doi.org/10.1186/s13075-022-02886-8

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