Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen

BACKGROUND: A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure. Angiotensinogen elimination raises concerns for clinical application because an angiotensin rise is needed to maintain perfusion pressure during hy...

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Detalles Bibliográficos
Autores principales: Uijl, Estrellita, Ye, Dien, Ren, Liwei, Mirabito Colafella, Katrina M., van Veghel, Richard, Garrelds, Ingrid M., Lu, Hong S., Daugherty, Alan, Hoorn, Ewout J., Nioi, Paul, Foster, Don, Danser, A. H. Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375483/
https://www.ncbi.nlm.nih.gov/pubmed/35876413
http://dx.doi.org/10.1161/JAHA.122.026426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375483/
https://www.ncbi.nlm.nih.gov/pubmed/35876413
http://dx.doi.org/10.1161/JAHA.122.026426

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