Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism

BACKGROUND: Parkinson’s disease (PD) is one of the most important neurodegenerative disorders in elderly people. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in a large proportion of the patients with sporadic and familial PD. Mutations can occur at different locations in the...

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Detalles Bibliográficos
Autores principales: Chen, Meng-Ling, Wu, Ruey-Meei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375908/
https://www.ncbi.nlm.nih.gov/pubmed/35965315
http://dx.doi.org/10.1186/s12929-022-00844-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375908/
https://www.ncbi.nlm.nih.gov/pubmed/35965315
http://dx.doi.org/10.1186/s12929-022-00844-9

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