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Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism
BACKGROUND: Parkinson’s disease (PD) is one of the most important neurodegenerative disorders in elderly people. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in a large proportion of the patients with sporadic and familial PD. Mutations can occur at different locations in the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375908/ https://www.ncbi.nlm.nih.gov/pubmed/35965315 http://dx.doi.org/10.1186/s12929-022-00844-9 |