Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a developmental disorder associated with epilepsy, autism, and cognitive impairment. Despite inactivating mutations in the TSC1 or TSC2 genes and hyperactive mechanistic target of rapamycin (mTOR) signaling, the mechanisms underlying TSC-associated neurological sy...

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Detalles Bibliográficos
Autores principales: Wu, Xiaoping, Sosunov, Alexander A., Lado, Wudu, Teoh, Jia Jie, Ham, Ahrom, Li, Hongyu, Al-Dalahmah, Osama, Gill, Brian J.A., Arancio, Ottavio, Schevon, Catherine A., Frankel, Wayne N., McKhann, Guy M., Sulzer, David, Goldman, James E., Tang, Guomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376014/
https://www.ncbi.nlm.nih.gov/pubmed/35858542
http://dx.doi.org/10.1016/j.celrep.2022.111085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376014/
https://www.ncbi.nlm.nih.gov/pubmed/35858542
http://dx.doi.org/10.1016/j.celrep.2022.111085

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