Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector

Proliferating cancer cells are dependent on glutamine metabolism for survival when challenged with oxidative stresses caused by reactive oxygen species, hypoxia, nutrient deprivation and matrix detachment. ATF4, a key stress responsive transcription factor, is essential for cancer cells to sustain g...

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Detalles Bibliográficos
Autores principales: Li, Ruizhi, Wilson, Kristin F., Cerione, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376072/
https://www.ncbi.nlm.nih.gov/pubmed/35963851
http://dx.doi.org/10.1038/s41420-022-01156-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376072/
https://www.ncbi.nlm.nih.gov/pubmed/35963851
http://dx.doi.org/10.1038/s41420-022-01156-5

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