Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Defective insulin processing is associated with obesity and diabetes. Prohormone convertase 1/3 (PC1/3) is an endopeptidase required for the processing of neurotransmitters and hormones. PC1/3 deficiency and genome-wide association studies relate PC1/3 with early onset obesity. Here, we find that de...

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Detalles Bibliográficos
Autores principales: Meier, Daniel T., Rachid, Leila, Wiedemann, Sophia J., Traub, Shuyang, Trimigliozzi, Kelly, Stawiski, Marc, Sauteur, Loïc, Winter, Denise V., Le Foll, Christelle, Brégère, Catherine, Guzman, Raphael, Odermatt, Alex, Böni-Schnetzler, Marianne, Donath, Marc Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376086/
https://www.ncbi.nlm.nih.gov/pubmed/35963866
http://dx.doi.org/10.1038/s41467-022-32509-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376086/
https://www.ncbi.nlm.nih.gov/pubmed/35963866
http://dx.doi.org/10.1038/s41467-022-32509-4

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