PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression

Autosomal dominant polycystic kidney disease (ADPKD), among the most common human genetic conditions and a frequent etiology of kidney failure, is primarily caused by heterozygous PKD1 mutations. Kidney cyst formation occurs when PKD1 dosage falls below a critical threshold. However, no framework ex...

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Detalles Bibliográficos
Autores principales: Lakhia, Ronak, Ramalingam, Harini, Chang, Chun-Mien, Cobo-Stark, Patricia, Biggers, Laurence, Flaten, Andrea, Alvarez, Jesus, Valencia, Tania, Wallace, Darren P., Lee, Edmund C., Patel, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376183/
https://www.ncbi.nlm.nih.gov/pubmed/35965273
http://dx.doi.org/10.1038/s41467-022-32543-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376183/
https://www.ncbi.nlm.nih.gov/pubmed/35965273
http://dx.doi.org/10.1038/s41467-022-32543-2

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