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Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells
Despite their clinical success, chimeric antigen receptor (CAR)-T cell therapies for B-cell malignancies are limited by lengthy, costly and labor-intensive ex vivo manufacturing procedures that may lead to cell products with heterogeneous composition. Here we describe an implantable, multifunctional...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376243/ https://www.ncbi.nlm.nih.gov/pubmed/35332339 http://dx.doi.org/10.1038/s41587-022-01245-x |