Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism

Multiple system atrophy with predominant parkinsonism (MSA-P) is a highly incapacitating disease with a short life expectancy and symptomatic therapy is still limited. In this report, we presented the case of a 65-year-old woman with a 3-year history of severe rigidity, bradykinesia, and gait dysfun...

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Autores principales: Li, Jiping, Mei, Shanshan, Zhang, Xiaohua, Wang, Yunpeng, Jia, Xiaofei, Liu, Jinlong, Xu, Erhe, Mao, Wei, Zhang, Yuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376352/
https://www.ncbi.nlm.nih.gov/pubmed/35979336
http://dx.doi.org/10.3389/fnins.2022.929273
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author Li, Jiping
Mei, Shanshan
Zhang, Xiaohua
Wang, Yunpeng
Jia, Xiaofei
Liu, Jinlong
Xu, Erhe
Mao, Wei
Zhang, Yuqing
author_facet Li, Jiping
Mei, Shanshan
Zhang, Xiaohua
Wang, Yunpeng
Jia, Xiaofei
Liu, Jinlong
Xu, Erhe
Mao, Wei
Zhang, Yuqing
author_sort Li, Jiping
collection PubMed
description Multiple system atrophy with predominant parkinsonism (MSA-P) is a highly incapacitating disease with a short life expectancy and symptomatic therapy is still limited. In this report, we presented the case of a 65-year-old woman with a 3-year history of severe rigidity, bradykinesia, and gait dysfunction alongside severe freezing of gait diagnosed with MSA-P. She underwent combined therapy of bilateral subthalamic nucleus deep brain stimulation (DBS) and low-thoracic spinal cord stimulation (SCS). The double-blind evaluation of the Movement Disorder Society Sponsored Revision of the Unified Parkinson’s Disease Rating Scale part III and 7-m Timed Up and Go at follow-ups showed her cardinal parkinsonian symptoms benefit significantly from DBS stimulation, while the improvement of SCS was mainly embodied in lower-limb symptoms. The combined stimulation achieved a better improvement of motor function than either DBS or SCS stimulation alone. Most notably, the improvement of lower-limb symptoms was significantly enhanced by the combined stimulation.
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spelling pubmed-93763522022-08-16 Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism Li, Jiping Mei, Shanshan Zhang, Xiaohua Wang, Yunpeng Jia, Xiaofei Liu, Jinlong Xu, Erhe Mao, Wei Zhang, Yuqing Front Neurosci Neuroscience Multiple system atrophy with predominant parkinsonism (MSA-P) is a highly incapacitating disease with a short life expectancy and symptomatic therapy is still limited. In this report, we presented the case of a 65-year-old woman with a 3-year history of severe rigidity, bradykinesia, and gait dysfunction alongside severe freezing of gait diagnosed with MSA-P. She underwent combined therapy of bilateral subthalamic nucleus deep brain stimulation (DBS) and low-thoracic spinal cord stimulation (SCS). The double-blind evaluation of the Movement Disorder Society Sponsored Revision of the Unified Parkinson’s Disease Rating Scale part III and 7-m Timed Up and Go at follow-ups showed her cardinal parkinsonian symptoms benefit significantly from DBS stimulation, while the improvement of SCS was mainly embodied in lower-limb symptoms. The combined stimulation achieved a better improvement of motor function than either DBS or SCS stimulation alone. Most notably, the improvement of lower-limb symptoms was significantly enhanced by the combined stimulation. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9376352/ /pubmed/35979336 http://dx.doi.org/10.3389/fnins.2022.929273 Text en Copyright © 2022 Li, Mei, Zhang, Wang, Jia, Liu, Xu, Mao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Jiping
Mei, Shanshan
Zhang, Xiaohua
Wang, Yunpeng
Jia, Xiaofei
Liu, Jinlong
Xu, Erhe
Mao, Wei
Zhang, Yuqing
Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
title Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
title_full Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
title_fullStr Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
title_full_unstemmed Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
title_short Case report: Combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
title_sort case report: combined therapy of bilateral subthalamic nucleus deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376352/
https://www.ncbi.nlm.nih.gov/pubmed/35979336
http://dx.doi.org/10.3389/fnins.2022.929273
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