A TLR4-independent critical role for CD14 in intracellular LPS sensing

Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome comprising caspase-4 or −11 governs antibacterial host defense. How LPS gains intracellular access in vivo is largely unknown. Here, we show that CD14—an LPS-binding protein with a well-documented role in TLR4 activation...

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Detalles Bibliográficos
Autores principales: Vasudevan, Swathy O., Russo, Ashley J., Kumari, Puja, Vanaja, Sivapriya Kailasan, Rathinam, Vijay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376664/
https://www.ncbi.nlm.nih.gov/pubmed/35508125
http://dx.doi.org/10.1016/j.celrep.2022.110755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376664/
https://www.ncbi.nlm.nih.gov/pubmed/35508125
http://dx.doi.org/10.1016/j.celrep.2022.110755

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