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Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations
[Image: see text] Human PAICS is a bifunctional enzyme that is involved in the de novo purine biosynthesis, catalyzing the conversion of aminoimidazole ribonucleotide (AIR) into N-succinylcarboxamide-5-aminoimidazole ribonucleotide (SAICAR). It comprises two distinct active sites, AIR carboxylase (A...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376930/ https://www.ncbi.nlm.nih.gov/pubmed/35914774 http://dx.doi.org/10.1021/jacs.2c05072 |