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Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations

[Image: see text] Human PAICS is a bifunctional enzyme that is involved in the de novo purine biosynthesis, catalyzing the conversion of aminoimidazole ribonucleotide (AIR) into N-succinylcarboxamide-5-aminoimidazole ribonucleotide (SAICAR). It comprises two distinct active sites, AIR carboxylase (A...

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Detalles Bibliográficos
Autores principales:	Prejanò, Mario, Škerlová, Jana, Stenmark, Pål, Himo, Fahmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376930/ https://www.ncbi.nlm.nih.gov/pubmed/35914774 http://dx.doi.org/10.1021/jacs.2c05072

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