Cargando…

Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations

[Image: see text] Human PAICS is a bifunctional enzyme that is involved in the de novo purine biosynthesis, catalyzing the conversion of aminoimidazole ribonucleotide (AIR) into N-succinylcarboxamide-5-aminoimidazole ribonucleotide (SAICAR). It comprises two distinct active sites, AIR carboxylase (A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prejanò, Mario, Škerlová, Jana, Stenmark, Pål, Himo, Fahmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376930/ https://www.ncbi.nlm.nih.gov/pubmed/35914774 http://dx.doi.org/10.1021/jacs.2c05072

Ejemplares similares

Mechanisms of metal-dependent non-redox decarboxylases from quantum chemical calculations
por: Sheng, Xiang, et al.
Publicado: (2021)

Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis
por: Prejanò, Mario, et al.
Publicado: (2021)

Status report on the quantum chemical cluster approach for modeling enzyme reactions
por: Himo, Fahmi, et al.
Publicado: (2022)

The Quantum Chemical Cluster Approach in Biocatalysis
por: Sheng, Xiang, et al.
Publicado: (2023)

Periodicity of the Affinity of Lanmodulin for Trivalent Lanthanides and Actinides: Structural and Electronic Insights from Quantum Chemical Calculations
por: Prejanò, Mario, et al.
Publicado: (2023)

Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion
por: Škerlová, Jana, et al.
Publicado: (2021)

Mechanism of the Kinugasa Reaction Revisited
por: Santoro, Stefano, et al.
Publicado: (2021)

Quantum Chemical Study of Dual-Substrate Recognition in ω-Transaminase
por: Manta, Bianca, et al.
Publicado: (2017)

Mechanism of 3‐Methylglutaconyl CoA Decarboxylase AibA/AibB: Pericyclic Reaction versus Direct Decarboxylation
por: Sheng, Xiang, et al.
Publicado: (2020)

A Theoretical Study of the Benzoylformate Decarboxylase Reaction Mechanism
por: Planas, Ferran, et al.
Publicado: (2018)

Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines
por: Meng, Minjun, et al.
Publicado: (2018)

Elucidating Direct Photolysis Mechanisms of Different Dissociation Species of Norfloxacin in Water and Mg(2+) Effects by Quantum Chemical Calculations
por: Wang, Se, et al.
Publicado: (2017)

Supplementary data for the quantum chemical calculation of free radical substitution reaction mechanism of camptothecin
por: Dai, Yujie, et al.
Publicado: (2018)

Quantum Chemistry as a Tool in Asymmetric Biocatalysis: Limonene Epoxide Hydrolase Test Case**
por: Lind, Maria E S, et al.
Publicado: (2013)

Quantum chemical calculations for reaction prediction in the development of synthetic methodologies
por: Hayashi, Hiroki, et al.
Publicado: (2023)

Quantum Chemical Calculations to Trace Back Reaction Paths for the Prediction of Reactants
por: Sumiya, Yosuke, et al.
Publicado: (2022)

Modeling the Reaction of Carboxylic Acids and Isonitriles in a Self‐Assembled Capsule
por: Daver, Henrik, et al.
Publicado: (2020)

PAICS is related to glioma grade and can promote glioma growth and migration
por: Du, Baoshun, et al.
Publicado: (2021)

Cofactor mobility determines reaction outcome in the IMPDH/GMPR (β/α)(8) barrel enzymes
por: Patton, Gregory C., et al.
Publicado: (2011)

A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression()
por: Chakravarthi, Balabhadrapatruni V.S.K., et al.
Publicado: (2018)

Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
por: Cheung, Chantal Hoi Yin, et al.
Publicado: (2019)

Pain Assessment in Impaired Cognition (PAIC15) Instrument: Cutoffs Against Three Standards
por: van der Steen, Jenny, et al.
Publicado: (2021)

Behavior of the E–E’ Bonds (E, E’ = S and Se) in Glutathione Disulfide and Derivatives Elucidated by Quantum Chemical Calculations with the Quantum Theory of Atoms-In-Molecules Approach
por: Hayashi, Satoko, et al.
Publicado: (2018)

MAPT and PAICE: Tools for time series and single time point transcriptionist visualization and knowledge discovery
por: Hosseini, Parsa, et al.
Publicado: (2012)

Diagnostic and Prognostic Value of TAT, PIC, TM, and t-PAIC in Malignant Tumor Patients With Venous Thrombosis
por: Zhou, Kun, et al.
Publicado: (2020)

PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer
por: Agarwal, Sumit, et al.
Publicado: (2020)

Adsorption of radionuclides on ferrocyanides: quantum-chemical calculations
por: Stasyuk, I V, et al.
Publicado: (2006)

Constant chemical potential approach for quantum chemical calculations in electrocatalysis
por: Schneider, Wolfgang B, et al.
Publicado: (2014)

Mechanisms of Formation and Rearrangement of Benziodoxole-Based CF(3) and SCF(3) Transfer Reagents
por: Brea, Oriana, et al.
Publicado: (2020)

Combined Experimental and Computational Study of Ruthenium N-Hydroxyphthalimidoyl Carbenes in Alkene Cyclopropanation Reactions
por: Planas, Ferran, et al.
Publicado: (2021)

The Intramolecular Diels-Alder Reaction of Diarylheptanoids — Quantum Chemical Calculation of Structural Features Favoring the Formation of Phenylphenalenones
por: Monakhova, Yulia, et al.
Publicado: (2014)

Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling
por: He, Jingxuan, et al.
Publicado: (2022)

The PAICE suite reveals circadian posttranscriptional timing of noncoding RNAs and spliceosome components in Mus musculus macrophages
por: Buel, Sharleen M, et al.
Publicado: (2022)

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer
por: Goswami, Moloy T., et al.
Publicado: (2015)

PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2
por: Huang, Nan, et al.
Publicado: (2020)

PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression
por: Agarwal, Sumit, et al.
Publicado: (2020)

Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of (13)C-Bicarbonate Incorporation
por: Shon, Hyungjoo, et al.
Publicado: (2022)

Quantum chemical elucidation of a sevenfold symmetric bacterial antenna complex
por: Cupellini, Lorenzo, et al.
Publicado: (2022)

Quantum-Chemical Quasi-Docking for Molecular Dynamics Calculations
por: Sulimov, Alexey, et al.
Publicado: (2022)

Quantum-chemical calculations of molecular systems as the basis of nanotechnologiesin applied quantum chemistry
por: Zaikov, GE, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_honnrui18o3lbticdeanakouf1