An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline

[Image: see text] Precision deuteration has become part of the medicinal chemist’s toolbox, but its usefulness can be undermined by unpredictable metabolic switch effects. Herein we report the deuteration of doxophylline, a drug used in the treatment of asthma and COPD that undergoes extensive oxida...

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Detalles Bibliográficos
Autores principales: Aprile, Silvio, Colombo, Giorgia, Serafini, Marta, Di Paola, Rosanna, Pisati, Federica, Bhela, Irene Preet, Cuzzocrea, Salvatore, Grosa, Giorgio, Pirali, Tracey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377007/
https://www.ncbi.nlm.nih.gov/pubmed/35978700
http://dx.doi.org/10.1021/acsmedchemlett.2c00166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377007/
https://www.ncbi.nlm.nih.gov/pubmed/35978700
http://dx.doi.org/10.1021/acsmedchemlett.2c00166

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