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An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
[Image: see text] Precision deuteration has become part of the medicinal chemist’s toolbox, but its usefulness can be undermined by unpredictable metabolic switch effects. Herein we report the deuteration of doxophylline, a drug used in the treatment of asthma and COPD that undergoes extensive oxida...
Autores principales: | Aprile, Silvio, Colombo, Giorgia, Serafini, Marta, Di Paola, Rosanna, Pisati, Federica, Bhela, Irene Preet, Cuzzocrea, Salvatore, Grosa, Giorgio, Pirali, Tracey |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377007/ https://www.ncbi.nlm.nih.gov/pubmed/35978700 http://dx.doi.org/10.1021/acsmedchemlett.2c00166 |
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