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Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells
BACKGROUND: The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and muscle repair. However, why FOS is rapidly downregulated before SCs enter cell cycl...
Autores principales: | Barutcu, A. Rasim, Elizalde, Gabriel, Gonzalez, Alfredo E., Soni, Kartik, Rinn, John L., Wagers, Amy J., Almada, Albert E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377060/ https://www.ncbi.nlm.nih.gov/pubmed/35971133 http://dx.doi.org/10.1186/s13395-022-00303-x |
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