Novel Group C Oncolytic Adenoviruses Carrying a miRNA Inhibitor Demonstrate Enhanced Oncolytic Activity In Vitro and In Vivo

Oncolytic adenoviruses (OAd) represent an attractive treatment option for cancer. Clinical efficacy of commonly utilized human adenovirus type 5 (Ad5)-based oncolytic viruses is limited by variable expression levels of the coxsackie- and adenovirus receptor (CAR) in tumor cells and high prevalence o...

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Detalles Bibliográficos
Autores principales: Doerner, Johannes, Sallard, Erwan, Zhang, Wenli, Solanki, Manish, Liu, Jing, Ehrke-Schulz, Eric, Zirngibl, Hubert, Lieber, André, Ehrhardt, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Models and Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377726/
https://www.ncbi.nlm.nih.gov/pubmed/35027480
http://dx.doi.org/10.1158/1535-7163.MCT-21-0240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377726/
https://www.ncbi.nlm.nih.gov/pubmed/35027480
http://dx.doi.org/10.1158/1535-7163.MCT-21-0240

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