CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization

NRG1 fusions are recurrent somatic genome alterations occurring across several tumor types, including invasive mucinous lung adenocarcinomas and pancreatic ductal adenocarcinomas and are potentially actionable genetic alterations in these cancers. We initially discovered CD74-NRG1 as the first NRG1...

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Detalles Bibliográficos
Autores principales: Werr, Lisa, Plenker, Dennis, Dammert, Marcel A., Lorenz, Carina, Brägelmann, Johannes, Tumbrink, Hannah L., Klein, Sebastian, Schmitt, Anna, Büttner, Reinhard, Persigehl, Thorsten, Shokat, Kevan M., Wunderlich, F. Thomas, Schram, Alison M., Peifer, Martin, Sos, Martin L., Reinhardt, H. Christian, Thomas, Roman K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Models and Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377738/
https://www.ncbi.nlm.nih.gov/pubmed/35247925
http://dx.doi.org/10.1158/1535-7163.MCT-21-0820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377738/
https://www.ncbi.nlm.nih.gov/pubmed/35247925
http://dx.doi.org/10.1158/1535-7163.MCT-21-0820

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