Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients with HGSC. Epigenetic silencing of immunostimulatory genes is implicated in immune evasion in H...

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Detalles Bibliográficos
Autores principales: Spiliopoulou, Pavlina, Spear, Sarah, Mirza, Hasan, Garner, Ian, McGarry, Lynn, Grundland-Freile, Fabio, Cheng, Zhao, Ennis, Darren P., Iyer, Nayana, McNamara, Sophie, Natoli, Marina, Mason, Susan, Blyth, Karen, Adams, Peter D., Roxburgh, Patricia, Fuchter, Matthew J., Brown, Bob, McNeish, Iain A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377747/
https://www.ncbi.nlm.nih.gov/pubmed/35131874
http://dx.doi.org/10.1158/1535-7163.MCT-21-0743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377747/
https://www.ncbi.nlm.nih.gov/pubmed/35131874
http://dx.doi.org/10.1158/1535-7163.MCT-21-0743

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