Cargando…

The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA

PURPOSE: Oncogenic kinase fusions are targetable with approved and investigational therapies and can also mediate acquired resistance (AR) to targeted therapy. We aimed to understand the clinical validity of liquid biopsy comprehensive genomic profiling (CGP) to detect kinase fusions pan tumor. EXPE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jessica K., Hazar-Rethinam, Mehlika, Decker, Brennan, Gjoerup, Ole, Madison, Russell W., Lieber, Daniel S., Chung, Jon H., Schrock, Alexa B., Creeden, James, Venstrom, Jeffrey, Alexander, Brian, Oxnard, Geoffrey R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Precision Medicine and Imaging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377769/ https://www.ncbi.nlm.nih.gov/pubmed/34753780 http://dx.doi.org/10.1158/1078-0432.CCR-21-2136

Ejemplares similares

Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors
por: Lee, Jessica K., et al.
Publicado: (2022)

Circulating Tumor DNA Monitoring on Chemo-immunotherapy for Risk Stratification in Advanced Non–Small Cell Lung Cancer
por: Pellini, Bruna, et al.
Publicado: (2023)

Detection of an ALK Fusion in Colorectal Carcinoma by Hybrid Capture‐Based Assay of Circulating Tumor DNA
por: Lai, Andrea Z., et al.
Publicado: (2017)

Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma
por: Rugo, Hope S., et al.
Publicado: (2023)

Tumor Fraction Correlates With Detection of Actionable Variants Across > 23,000 Circulating Tumor DNA Samples
por: Husain, Hatim, et al.
Publicado: (2022)

Characterization of Non–Small-Cell Lung Cancers With MET Exon 14 Skipping Alterations Detected in Tissue or Liquid: Clinicogenomics and Real-World Treatment Patterns
por: Lee, Jessica K., et al.
Publicado: (2021)

74325 Vast sex-specific differences in transcriptional landscapes of pancreatic neuroendocrine tumors
por: Ivanov, Nikolay A., et al.
Publicado: (2021)

Genomic landscape of 891 RET fusions detected across diverse solid tumor types
por: Parimi, Vamsi, et al.
Publicado: (2023)

ERBB2 Copy Number as a Quantitative Biomarker for Real-World Outcomes to Anti–Human Epidermal Growth Factor Receptor 2 Therapy in Advanced Gastroesophageal Adenocarcinoma
por: Zhang, Liangliang, et al.
Publicado: (2022)

Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer
por: Sivakumar, Smruthy, et al.
Publicado: (2022)

Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer
por: Graf, Ryon P., et al.
Publicado: (2022)

The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
por: Hazar-Rethinam, Mehlika, et al.
Publicado: (2011)

The Landscape of Tumor Fusion Neoantigens: A Pan-Cancer Analysis
por: Wei, Zhiting, et al.
Publicado: (2019)

4565 Sex-Specific Differences in the Genomic Landscape of Pediatric and Adult Glioblastoma
por: Ivanov, Nikolay A., et al.
Publicado: (2020)

Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma
por: Burgener, Justin M., et al.
Publicado: (2021)

Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer
por: Graf, Ryon P., et al.
Publicado: (2022)

Pan-tumor landscape of fibroblast growth factor receptor 1-4 genomic alterations
por: Murugesan, K., et al.
Publicado: (2022)

Homologous Recombination Deficiency Landscape of Breast Cancers and Real-World Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Patients With Somatic BRCA1/2, Germline PALB2, or Homologous Recombination Deficiency Signature
por: Batalini, Felipe, et al.
Publicado: (2023)

Learning Individual Survival Models from PanCancer Whole Transcriptome Data
por: Kumar, Neeraj, et al.
Publicado: (2023)

The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation
por: Gopal, Priyanka, et al.
Publicado: (2022)

4108 Artificial Intelligence-Based Quantification of the General Movement Assessment Using Center of Pressure Patterns in Healthy Infants
por: Johnson, Tara Lynn, et al.
Publicado: (2020)

Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA
por: Chen, Xiaoji, et al.
Publicado: (2021)

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes
por: Meagher, Nicola S., et al.
Publicado: (2022)

Pan-cancer Analysis of Homologous Recombination Repair–associated Gene Alterations and Genome-wide Loss-of-Heterozygosity Score
por: Westphalen, C. Benedikt, et al.
Publicado: (2022)

(18)F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition
por: Reeves, Kirsten M., et al.
Publicado: (2022)

Prevalence of UV Mutational Signatures Among Cutaneous Primary Tumors
por: Mata, Douglas A., et al.
Publicado: (2022)

Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma
por: Madanat-Harjuoja, Laura M., et al.
Publicado: (2022)

HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA
por: Leung, Eric, et al.
Publicado: (2021)

VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
por: Cheng, Vinton W.T., et al.
Publicado: (2022)

Circulating Tumor DNA in Stage III Colorectal Cancer, beyond Minimal Residual Disease Detection, toward Assessment of Adjuvant Therapy Efficacy and Clinical Behavior of Recurrences
por: Henriksen, Tenna Vesterman, et al.
Publicado: (2022)

A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases
por: Wang, Victoria E., et al.
Publicado: (2017)

266 Decoding the role of polyamine metabolism on anti-tumor immunity in head and neck cancer
por: Harbison, Richard Alexander, et al.
Publicado: (2023)

Gallium-68–labeled Peptide PET Quantifies Tumor Exposure of PD-L1 Therapeutics
por: Mishra, Akhilesh, et al.
Publicado: (2023)

Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition
por: Martin, John D., et al.
Publicado: (2022)

Early circulating tumor DNA dynamics as a pan‐tumor biomarker for long‐term clinical outcome in patients treated with durvalumab and tremelimumab
por: Kansara, Maya, et al.
Publicado: (2022)

Diagnostic Performance of a Tumor Marker Gene Test to Personalize Serum CA19–9 Reference Ranges
por: Dbouk, Mohamad, et al.
Publicado: (2023)

Auranofin is a potent suppressor of osteosarcoma metastasis
por: Topkas, Eleni, et al.
Publicado: (2015)

Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
por: Fisher, Natalie C., et al.
Publicado: (2022)

Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response
por: Zhou, Qing, et al.
Publicado: (2022)

Circulating Tumor DNA Analysis in Advanced Urothelial Carcinoma: Insights from Biological Analysis and Extended Clinical Follow-up
por: Lindskrog, Sia V., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cmta44lfjtnulmgb1hh5mepq02