Discovery and Characterization of Multiple Classes of Human CatSper Blockers

The cation channel of sperm (CatSper) is a validated target for nonhormonal male contraception, but it lacks selective blockers, hindering studies to establish its role in both motility and capacitation. Via an innovative calcium uptake assay utilizing human sperm we discovered novel inhibitors of C...

Descripción completa

Detalles Bibliográficos
Autores principales: Carlson, Erick J., Francis, Rawle, Liu, Yutong, Li, Ping, Lyon, Maximilian, Santi, Celia M., Hook, Derek J., Hawkinson, Jon E., Georg, Gunda I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378630/
https://www.ncbi.nlm.nih.gov/pubmed/35644882
http://dx.doi.org/10.1002/cmdc.202000499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378630/
https://www.ncbi.nlm.nih.gov/pubmed/35644882
http://dx.doi.org/10.1002/cmdc.202000499

Ejemplares similares