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Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

Delayed oligodendrocyte (OL) maturation caused by hypoxia (Hx)-induced neonatal brain injury results in hypomyelination and leads to neurological disabilities. Previously, we characterized Sirt1 as a crucial regulator of OL progenitor cell (OPC) proliferation in response to Hx. We now identify Sirt2...

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Detalles Bibliográficos
Autores principales: Jablonska, Beata, Adams, Katrina L., Kratimenos, Panagiotis, Li, Zhen, Strickland, Emma, Haydar, Tarik F., Kusch, Katharina, Nave, Klaus-Armin, Gallo, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378658/
https://www.ncbi.nlm.nih.gov/pubmed/35970992
http://dx.doi.org/10.1038/s41467-022-32462-2