Design and synthesis of new N-thioacylated ciprofloxacin derivatives as urease inhibitors with potential antibacterial activity

A new series of N-thioacylated ciprofloxacin 3a–n were designed and synthesized based on Willgerodt–Kindler reaction. The results of in vitro urease inhibitory assay indicated that almost all the synthesized compounds 3a–n (IC(50) = 2.05 ± 0.03–32.49 ± 0.32 μM) were more potent than standard inhibit...

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Detalles Bibliográficos
Autores principales: Pedrood, Keyvan, Azizian, Homa, Montazer, Mohammad Nazari, Moazzam, Ali, Asadi, Mehdi, Montazeri, Hamed, Biglar, Mahmood, Zamani, Mozhdeh, Larijani, Bagher, Zomorodian, Kamiar, Mohammadi-Khanaposhtani, Maryam, Irajie, Cambyz, Amanlou, Massoud, Iraji, Aida, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378659/
https://www.ncbi.nlm.nih.gov/pubmed/35970866
http://dx.doi.org/10.1038/s41598-022-17993-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378659/
https://www.ncbi.nlm.nih.gov/pubmed/35970866
http://dx.doi.org/10.1038/s41598-022-17993-4

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