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Glycosylated modification of MUC1 maybe a new target to promote drug sensitivity and efficacy for breast cancer chemotherapy

Breast cancer, the most common cancer in women, usually exhibits intrinsic insensitivity to drugs, even without drug resistance. MUC1 is a highly glycosylated transmembrane protein, overexpressed in breast cancer, contributing to tumorigenesis and worse prognosis. However, the molecular mechanism be...

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Detalles Bibliográficos
Autores principales: Xi, Xiaomin, Wang, Jiting, Qin, Yue, Huang, Weidong, You, Yilin, Zhan, Jicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378678/
https://www.ncbi.nlm.nih.gov/pubmed/35970845
http://dx.doi.org/10.1038/s41419-022-05110-2