A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA

Productive transcriptional elongation of many cellular and viral mRNAs requires transcriptional factors to extract pTEFb from the 7SK snRNP by modulating the association between HEXIM and 7SK snRNA. In HIV-1, Tat binds to 7SK by displacing HEXIM. However, without the structure of the 7SK-HEXIM compl...

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Detalles Bibliográficos
Autores principales: Pham, Vincent V., Gao, Michael, Meagher, Jennifer L., Smith, Janet L., D’Souza, Victoria M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378691/
https://www.ncbi.nlm.nih.gov/pubmed/35970937
http://dx.doi.org/10.1038/s42003-022-03734-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378691/
https://www.ncbi.nlm.nih.gov/pubmed/35970937
http://dx.doi.org/10.1038/s42003-022-03734-w

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