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A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA
Productive transcriptional elongation of many cellular and viral mRNAs requires transcriptional factors to extract pTEFb from the 7SK snRNP by modulating the association between HEXIM and 7SK snRNA. In HIV-1, Tat binds to 7SK by displacing HEXIM. However, without the structure of the 7SK-HEXIM compl...
Autores principales: | Pham, Vincent V., Gao, Michael, Meagher, Jennifer L., Smith, Janet L., D’Souza, Victoria M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378691/ https://www.ncbi.nlm.nih.gov/pubmed/35970937 http://dx.doi.org/10.1038/s42003-022-03734-w |
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