Structures of UBA6 explain its dual specificity for ubiquitin and FAT10

The covalent modification of target proteins with ubiquitin or ubiquitin-like modifiers is initiated by E1 activating enzymes, which typically transfer a single modifier onto cognate conjugating enzymes. UBA6 is an unusual E1 since it activates two highly distinct modifiers, ubiquitin and FAT10. Her...

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Detalles Bibliográficos
Autores principales: Truongvan, Ngoc, Li, Shurong, Misra, Mohit, Kuhn, Monika, Schindelin, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378703/
https://www.ncbi.nlm.nih.gov/pubmed/35970836
http://dx.doi.org/10.1038/s41467-022-32040-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378703/
https://www.ncbi.nlm.nih.gov/pubmed/35970836
http://dx.doi.org/10.1038/s41467-022-32040-6

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