Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integrin α2β1

In Alport mice, activation of the endothelin A receptor (ET(A)R) in mesangial cells results in sub‐endothelial invasion of glomerular capillaries by mesangial filopodia. Filopodia deposit mesangial matrix in the glomerular basement membrane (GBM), including laminin 211 which activates NF‐κB, resulti...

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Detalles Bibliográficos
Autores principales: Madison, Jacob, Wilhelm, Kevin, Meehan, Daniel T, Delimont, Duane, Samuelson, Gina, Cosgrove, Dominic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378723/
https://www.ncbi.nlm.nih.gov/pubmed/35607980
http://dx.doi.org/10.1002/path.5969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378723/
https://www.ncbi.nlm.nih.gov/pubmed/35607980
http://dx.doi.org/10.1002/path.5969

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