Cancer-Associated Fibroblasts Suppress CD8(+) T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

Immune-checkpoint blockade (ICB) promotes antitumor immune responses and can result in durable patient benefit. However, response rates in breast cancer patients remain modest, stimulating efforts to discover novel treatment options. Cancer-associated fibroblasts (CAF) represent a major component of...

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Detalles Bibliográficos
Autores principales: Jenkins, Liam, Jungwirth, Ute, Avgustinova, Alexandra, Iravani, Marjan, Mills, Adam, Haider, Syed, Harper, James, Isacke, Clare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379365/
https://www.ncbi.nlm.nih.gov/pubmed/35749591
http://dx.doi.org/10.1158/0008-5472.CAN-21-4141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379365/
https://www.ncbi.nlm.nih.gov/pubmed/35749591
http://dx.doi.org/10.1158/0008-5472.CAN-21-4141

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