Pre-existing anti-drug antibodies in Fabry disease show less affinity for pegunigalsidase alfa

We analyzed the cross-reactivity of anti-drug antibodies (ADAs) against agalsidase-alfa and -beta from 49 patients with Fabry disease (FD) against the novel PEGylated enzyme pegunigalsidase-alfa (PRX-102). The affinity of purified anti-AGAL antibodies from pooled patient sera was significantly lower...

Descripción completa

Detalles Bibliográficos
Autores principales: Lenders, Malte, Pollmann, Solvey, Terlinden, Melina, Brand, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379515/
https://www.ncbi.nlm.nih.gov/pubmed/35990747
http://dx.doi.org/10.1016/j.omtm.2022.07.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379515/
https://www.ncbi.nlm.nih.gov/pubmed/35990747
http://dx.doi.org/10.1016/j.omtm.2022.07.009

Ejemplares similares