Neuron‐specific translational control shift ensures proteostatic resilience during ER stress

Proteostasis is essential for cellular survival and particularly important for highly specialised post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase R‐like endoplasmic reticulum (ER) kinase (PERK)‐mediated phosphorylation of eukaryotic translation initiati...

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Detalles Bibliográficos
Autores principales: Wolzak, Kimberly, Nölle, Anna, Farina, Margherita, Abbink, Truus EM, van der Knaap, Marjo S, Verhage, Matthijs, Scheper, Wiep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379547/
https://www.ncbi.nlm.nih.gov/pubmed/35791631
http://dx.doi.org/10.15252/embj.2021110501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379547/
https://www.ncbi.nlm.nih.gov/pubmed/35791631
http://dx.doi.org/10.15252/embj.2021110501

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