Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase

Although amyloid fibres are highly stable protein aggregates, a specific combination of human Hsp70 system chaperones can disassemble them, including fibres formed of α‐synuclein, huntingtin, or Tau. Disaggregation requires the ATPase activity of the constitutively expressed Hsp70 family member, Hsc...

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Detalles Bibliográficos
Autores principales: Beton, Joseph George, Monistrol, Jim, Wentink, Anne, Johnston, Erin C, Roberts, Anthony John, Bukau, Bernd Gerhard, Hoogenboom, Bart W, Saibil, Helen R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379549/
https://www.ncbi.nlm.nih.gov/pubmed/35698800
http://dx.doi.org/10.15252/embj.2021110410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379549/
https://www.ncbi.nlm.nih.gov/pubmed/35698800
http://dx.doi.org/10.15252/embj.2021110410

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