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QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-Lactamases
[Image: see text] β-lactam antibiotic resistance in Gram-negative bacteria, primarily caused by β-lactamase enzymes that hydrolyze the β-lactam ring, has become a serious clinical problem. Carbapenems were formerly considered “last resort” antibiotics because they escaped breakdown by most β-lactama...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379904/ https://www.ncbi.nlm.nih.gov/pubmed/35877936 http://dx.doi.org/10.1021/acsinfecdis.2c00152 |