Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

A central goal of genetics is to define the relationships between genotypes and phenotypes. High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single-cell RNA-sequencing readouts) enable massively parallel functional genomic mapping but, to date, have been used at limited...

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Detalles Bibliográficos
Autores principales: Replogle, Joseph M., Saunders, Reuben A., Pogson, Angela N., Hussmann, Jeffrey A., Lenail, Alexander, Guna, Alina, Mascibroda, Lauren, Wagner, Eric J., Adelman, Karen, Lithwick-Yanai, Gila, Iremadze, Nika, Oberstrass, Florian, Lipson, Doron, Bonnar, Jessica L., Jost, Marco, Norman, Thomas M., Weissman, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380471/
https://www.ncbi.nlm.nih.gov/pubmed/35688146
http://dx.doi.org/10.1016/j.cell.2022.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380471/
https://www.ncbi.nlm.nih.gov/pubmed/35688146
http://dx.doi.org/10.1016/j.cell.2022.05.013

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