Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours

OBJECTIVE: Stromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), which...

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Detalles Bibliográficos
Autores principales: Huang, Hsi-Chien, Sung, Yun-Chieh, Li, Chung-Pin, Wan, Dehui, Chao, Po-Han, Tseng, Yu-Ting, Liao, Bo-Wen, Cheng, Hui-Teng, Hsu, Fu-Fei, Huang, Chieh-Cheng, Chen, Yi-Ting, Liao, Yu-Hui, Hsieh, Hsin Tzu, Shih, Yu-Chuan, Liu, I-Ju, Wu, Han-Chung, Lu, Tsai-Te, Wang, Jane, Chen, Yunching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380514/
https://www.ncbi.nlm.nih.gov/pubmed/34921062
http://dx.doi.org/10.1136/gutjnl-2021-325180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380514/
https://www.ncbi.nlm.nih.gov/pubmed/34921062
http://dx.doi.org/10.1136/gutjnl-2021-325180

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